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Childhood Adenotonsillectomy Trial


Multi-center randomized trial comparing early adenotonsillectomy to watchful waiting plus supportive care.


464 children aged 5-9.9 years with mild to moderate obstructive sleep apnea.


2007-2012, subjects had two visits – baseline and 7-month follow-up.


National Heart, Lung, and Blood Institute


The Childhood Adenotonsillectomy Trial (CHAT) is a multi-center, single-blind, randomized, controlled trial designed to test whether after a 7-month observation period, children, ages 5 to 9.9 years, with mild to moderate obstructive sleep apnea randomized to early adenotonsillectomy (eAT) will show greater levels of neurocognitive functioning, specifically in the attention-executive functioning domain, than children randomized to watchful waiting plus supportive care (WWSC). Other outcomes assessed included other indices of neurocognitive functioning (learning and memory, information processing, etc.), physical growth, blood pressure, metabolic profile, symptoms and quality of life. Physiological measures of sleep were assessed at baseline and at 7-months with standardized full polysomnography with central scoring at the Brigham and Women’s Sleep Reading Center. In total, 1,447 children had screening polysomnographs and 464 were randomized to treatment.

Read more about CHAT at ClinicalTrials.gov (NCT00560859).

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Marcus CL, Moore RH, Rosen CL, Giordani B, Garetz SL, Taylor HG, Mitchell RB, Amin R, Katz ES, Arens R, Paruthi S, Muzumdar H, Gozal D, Thomas NH, Ware J, Beebe D, Snyder K, Elden L, Sprecher RC, Willging P, Jones D, Bent JP, Hoban T, Chervin RD, Ellenberg SS, Redline S; Childhood Adenotonsillectomy Trial (CHAT). A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013 Jun 20;368(25):2366-76. doi: 10.1056/NEJMoa1215881. Epub 2013 May 21. PMID: 23692173; PMCID: PMC3756808.

Please include the following text in the Acknowledgements:

The Childhood Adenotonsillectomy Trial (CHAT) was supported by the National Institutes of Health (HL083075, HL083129, UL1-RR-024134, UL1 RR024989). The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/datasets (introduction)
Core data from the CHAT study.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from the CHAT study.

Protocols and manuals



Heart Rate Variability (HRV) Analysis

Read about the methods, validation, and results for the NSRR HRV analysis efforts. There are summary datasets available and the included variables can be browsed here.

Thoraco-Abdominal Asynchrony Analysis (TAA)

NSRR user Mathias Baumert and colleagues conducted a specialized analysis using the CHAT polysomnography data. TAA result variables have been added to the baseline and follow-up datasets.

Read more about the results and methods in their publication.

Recent changes

Publication links

National Sleep Research Resource
Childhood Adenotonsillectomy Trial