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Blog

The Aging Slow Wave

Article Citation McConnell, B. V., Kronberg, E., Teale, P. D., Sillau, S. H., Fishback, G. M., Kaplan, R. I., ... & Bettcher, B. M. (2021). The aging slow wave: a shifting amalgam of distinct slow wave and spindle coupling subtypes define slow wave sleep across the human lifespan, Sleep, Volume 44, Issue 10, October 2021, zsab125, https://doi.org/10. Keep reading

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By michaelprerau on November 29, 2021 Nov 29, 2021 in Guest Blogger

Navigating the spectral slopes of the NSRR cohorts

Nataliia Kozhemiako & Shaun Purcell We recently used NSRR data to study the so-called spectral slope of the electroencephalogram (EEG), during wake, NREM and REM sleep. This work (described in a bioRxiv pre-print, Kozhemiako et al.) points to the power of NSRR data: thousands of polysomnographic studies that can be rapidly and freely repurposed to address a broad array of research questions. Keep reading

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By shaunpurcell on November 8, 2021 Nov 8, 2021 in Data Notes

ENIGMA-Sleep working group: An international sleep collaboration

What is the ENIGMA-Sleep? The Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA) consortium is a global collaboration of over 1400 scientists across 43 countries, studying neuropsychiatric illnesses and provides a powerful collaborative framework around the world. ENIGMA has more than 50 working groups, pooling large-scale coordinated data and expertise to answer fundamental clinical and neuroscientific questions, which offers testing reproducibility and robustness of findings (1). Keep reading

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By michaelprerau on September 20, 2021 Sep 20, 2021 in Guest Blogger

The NSRR Cohort Matrix: An easier way to explore the NSRR datasets

The NSRR is constantly developing new tools to improve its user experience. One of the newly developed applications, as inspired by the Dementias Platform, is the Cohort Matrix. The NSRR cohort matrix consists of three tabs: "Cohort Overview" tab provides summary of the key characteristics (e.g. sample size, age range, license, etc.), sleep data availability (e.g. polysomnography EDF files, actigraphy, etc.) and links back to the dataset introduction page. Keep reading

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By yzhang on August 26, 2021 Aug 26, 2021 in Releases

Arousal Burden is Linked with Long-Term Cardiovascular and All-Cause Mortality

Guest Blogger: Mattias Baumert Overview What is the problem being addressed? Our objective was to quantify the burden of cortical arousals throughout sleep and determine its association with long-term cardiovascular (CV) and overall mortality. What was the approach to solving the problem? We quantified arousal burden (AB) as the cumulative duration of all arousal events relative to total sleep time in three large cohort studies. Keep reading

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By michaelprerau on June 16, 2021 Jun 16, 2021 in Guest Blogger

Improving clinical trials with propensity score weighting

In an effort to highlight new and exciting work related to the NSRR, we are featuring guest blog posts from authors who have recently published using NSRR data. The following references: Zeng S, Li F, Wang R, Li F. Propensity score weighting for covariate adjustment in randomized clinical trials. Statistics in Medicine. 2020;1–17. https://doi.org/10.1002/sim.8805 Please contact support@sleepdata.org if you have new work you would like to share in a guest blog post. Keep reading

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By NSRR on January 5, 2021 Jan 5, 2021 in Guest Blogger

AHI Uncertainty: How Many Patients are Being Denied Treatment Due to Chance?

A patient's apnea-hypopnea index (AHI) determines whether or not they are eligible for reimbursable treatment. But how certain can we be that a patient's AHI is actually above or below a clinical threshold? In this study using 2049 subjects from MESA dataset from NSRR, we develop a metric for computing a confidence interval around a patient's AHI. Keep reading

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By michaelprerau on November 16, 2020 Nov 16, 2020 in Showcase

NHLBI Continues Its Support of the National Sleep Research Resource

Brigham and Women's Hospital, June 9, 2020 – The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), has announced that the National Sleep Research Resource (NSRR), hosted by Brigham and Women's Hospital, was awarded a five-year contract, facilitating an expansion of capabilities and providing support for increased community involvement. Keep reading

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By NSRR on June 9, 2020 Jun 9, 2020 in News

nuMoM2b dataset released

The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), which began in 2010, studies pregnant women who will be delivering for the first time (nulliparous women). This prospective cohort study evaluates the underlying, interrelated mechanisms of several common adverse pregnancy outcomes, which can be unpredictable in women who have little or no pregnancy history, to help guide their treatment. Keep reading

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By mrueschman on April 9, 2020 Apr 9, 2020 in Releases

Visualizing NSRR data

To paraphrase the adage, a picture is worth a thousand numbers. In order to investigate some basic properties of NSRR datasets, here we generate a number of whole-dataset visualizations. To make sense of these images, we’ll employ a remarkably complex computational pattern recognition and dimension reduction framework, a.k.a. the human visual system. Keep reading

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By shaunpurcell on January 22, 2020 Jan 22, 2020 in Data Notes